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PB-22 and 5F-PB-22 were the 1st synthetic cannabinoids to include a quinoline substructure and an ester linkage. These compounds are considered to have been synthesized Along with the intention of making a synthetic cannabinoid prodrug, which might strengthen absorption and confound detection. Ester bonds are easily biodegradable by way of spontaneous or endogenous, nonspecific esterase hydrolysis, that has been typically Utilized in medicinal chemistry to help make ester prodrugs.
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